The pleiotropic benefits of statins

Author: chnf

August undefined, 2024

WebbEvidence for the pleiotropic effects of statins in heart failure comes largely from retrospective and subgroup analyses of large studies. When statin therapy is compared … Webb13 apr. 2016 · PDF On Apr 13, 2016, Kirk Pappan published Why HMG Could be the Signal Responsible for the Pleiotropic Effect of Statins Pleiotropic Find, read and cite all the research you need on ResearchGate

Benefit–risk assessment of pitavastatin for the treatment of ...

Webb1 juni 2004 · These non-lipid-lowering (pleiotropic) effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction by decreasing LDL oxidation and increasing nitric oxide bioavailability. WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, geranylgeranlpyrophosphate (GGPP). Therefore, increasing mevalonate or GGPP concentrations within extra hepatic cells could limit the benefits of statins. cityblueshop

Effect of Statins on the Risk of Poststroke Pneumonia: National ...

WebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of endothelial function, modulation of immune function, and other pleiotropic cardiovascular benefits of statins, as well as in the fact that a number of other drugs that lower LDL … Webb8 apr. 2024 · The greatest improvements were recorded in the fluvastatin and dual therapy groups, suggesting the statin had played a dominant role. 28 Remarkably, a significant increase in nitric oxide and reduction in endothelin-1 was observed in the two groups receiving statins, indicating that the pleiotropic effects of this drug are fundamental for … Webb19 apr. 2010 · This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. References. Buhaescu I., Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications . ... Statins: Risk-Benefits and Role in Treating Dyslipidemias. dick\u0027s hunting boots

Frontiers Hydrophilic or Lipophilic Statins?

Pleiotropic effects of the HMG-CoA reductase inhibitors

WebbStatins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide (NO) bioavailability. AMP-activated protein kinase (AMPK) plays a central role in controlling energy and metabolism homeostasis in various organs. We therefore studied whether statins can activate AMPK, and if so, whether the activated ... Webb1 feb. 2015 · The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions due to their unique protein cargo. dick\\u0027s hyundaiWebb5 jan. 2012 · Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory … city blue shoes philadelphia

"Webb3 okt. 2024 · ObjectiveTo conduct risk assessment and assess the choice of statins ... with no difference between urban and rural areas. 6 Given the burden of CVD and lipid-lowering benefits of statins, ... cholesterol is present in 25% to 30% of urban and 15% to 20% rural subjects. 7 Statins have lipid lowering and number of pleiotropic ... " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

The Role of Statins in the Management of Heart Failure with …

WebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, … Webb15 mars 2024 · Ultimately, the benefits of statins in an infection setting appear to require attention to the underlying host response and to the timing of the dosage. From this …

Did you know?

Webb12 juni 2015 · This finding “suggests that reduction of LDL cholesterol levels per se explains the effect of statins on coronary heart disease,” rather than some pleiotropic benefit specific to statins, the editorialists wrote. “It’s nice to have all the different options for patients,” Cannon said. WebbThe pleiotropic benefits of statins may result from their impact on vascular inflammation. The molecular process underlying this phenomenon is not fully elucidated. Here, RNA …

Webb7 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis Main. Atherosclerosis is a lipoprotein-driven, inflammatory process underlying heart attack and stroke and is … Webb30 apr. 2024 · This misconception, and therefore reluctance to prescribe statins, may indirectly deny patients with chronic liver disease significant clinical benefit (Fig. 1).Unrelated to its lipid-lowering effects, statins have a wide array of pleiotropic effects, ranging from antioxidant, antifibrotic, anti-inflammatory, and improvement of endothelial …

Webb26 okt. 2024 · Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a … Webb10 mars 2015 · In summary, statins are probably both under- and over-utilized in older adults. For example, it is estimated that only 40-60% of patients over 65 are prescribed a statin after an acute MI; 24 conversely, a recent study found that 30% of patients with a cancer diagnosis were dispensed a statin within 30 days of dying. 25 For primary …

WebbBeneficial Cardiovascular Pleiotropic Effects of Statins Jean Davignon, MD Abstract—Pleiotropic effects of a drug are actions other than those for which the agent …

WebbThe noncausal theory supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque … dick\u0027s huntington wv dick\u0027s hyundaiWebb17 okt. 2024 · However, the clinical benefit of statin-induced elevation of HDL-cholesterol is unclear from trial data, ... statins have pleiotropic benefits including prevention of LDL oxidation. View full-text. citybluestore.com.brWebbDOI: 10.1016/S1734-1140(10)70247-4 Corpus ID: 4742496; Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. @article{Meda2010EffectsOS, title={Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells.}, author={Claudia Meda and Christian Plank and … dick\u0027s hunting gearWebb20 maj 2024 · One of the factors to be considered when evaluating outcomes of lipid-lowering treatment with statins is their solubility. Therefore, the role of both hydrophilic … dick\u0027s huntington beachWebb22 juli 2024 · As a result of their pleiotropic effects statins modulate virtually all known processes of atherosclerosis and have beneficial effects outside the cardiovascular … dick\\u0027s hyundai hillsboroWebbAlthough some trials evaluating the effects of statins on kidney disease outcomes have shown benefits of statins, 16,17,33 others have shown no effect. 18,34,35 However, most of these studies ... Dhawan V, Sharma PL, Kumar P. Pleiotropic effects of statins: new therapeutic targets in drug design. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(7 ... dick\u0027s hunting clothes