Polyphosphate kinase 2 family protein

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August undefined, 2024

WebApr 13, 2024 · A small ADP-ribose-factor-like RAS family GTPase that mediates lysosomal transport driven by kinesin: ... Leucine-rich repeat kinase 2: MAPK: Mitogen-activated protein kinase: mTOR: Mammalian target of rapamycin: Nrf2: ... Skeletal muscle and kidney-enriched inositol polyphosphate 5-phosphatase: STAT 3: Signal transducer and ... WebDec 5, 2024 · Inorganic polyphosphate (polyP) has been implicated in an astonishing array of biological functions, ranging from phosphorus storage to molecular chaperone activity …

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http://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.04.032 WebPolyphosphate kinase 2 family protein Imported. Gene names. ORF names. E0686_15645 Imported. Organism names. Organism. Deinococcus sp. S9 Imported. Taxonomic … pork loin pounded thin

Biochemical and structural characterization of polyphosphate …

WebApr 19, 2011 · Inorganic polyphosphate (polyP) plays a number of critical roles in bacterial persistence, stress, and virulence. PolyP intracellular metabolism is regulated by the polyphosphate kinase (PPK) protein families, and inhibition of PPK activity is a potential approach to disrupting polyP-dependent processes in pathogenic organisms. WebJul 1, 2005 · Overall structure of Escherichia coli polyphosphate kinase (PPK). (A) Structure of the PPK dimer in the asymmetric unit. The N-terminal domain of both subunits … WebJul 1, 2005 · Overall structure of Escherichia coli polyphosphate kinase (PPK). (A) Structure of the PPK dimer in the asymmetric unit. The N-terminal domain of both subunits (residues 2–106) is coloured in blue, the head domain (residues 107–321) in green, the C-terminal domain C1 (residues 322–502) in yellow and domain C2 (residues 503–687) in red. pork loin pit boss

Substrate recognition and mechanism revealed by ligand-bound ... - PN…

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WebFeb 14, 2014 · Abstract. Inorganic polyphosphate (polyP) is a linear polymer of tens to hundreds of phosphate (Pi) residues linked by "high-energy" phosphoanhydride bonds as in ATP. PolyP kinases, responsible for the synthesis and utilization of polyP, are divided into two families (PPK1 and PPK2) due to differences in amino acid sequence and kinetic … WebMar 17, 2016 · inositol polyphosphate kinase, putative (IPK2) TDO/A (1) PF3D7_1324800: dihydrofolate synthase/folylpolyglutamate synthase (DHFS-FPGS) QDO/A (1) PF3D7_1326600: conserved Plasmodium protein, unknown function: QDO/A (2) PF3D7_1336600: conserved Plasmodium protein, unknown function: TDO/A (1) … pork loin pressure cooker recipeWebApr 29, 2008 · Crystal structure of putative polyphosphate kinase 2 from Pseudomonas aeruginosa PA01. ... Here, we present structural and functional characterization of the PPK2 family. Proteins with a single PPK2 domain catalyze polyP-dependent phosphorylation of ADP to ATP, whereas proteins containing 2 fused PPK2 domains phosphorylate AMP to … pork loin on grill recipe

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Polyphosphate kinase 2 family protein

A polyphosphate kinase (PPK2) widely conserved in bacteria.

WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … WebMar 12, 2024 · Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures. ...

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WebJul 13, 2024 · Inorganic polyphosphate (polyP) is a crucial metabolite that can affect the ability of bacteria to survive and infect hosts. Intracellular polyP levels are controlled by by the polyphosphate kinase (PPK) protein families, and inhibition of PPK activity can potentially disrupt polyP-dependent processes in pathogens. WebCalcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis, and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate signaling pathways that control a broad range of physiological as well as pathological cellular events, including those important to cellular excitability, cell cycle, gene …

WebJul 27, 2016 · Polyphosphate kinases of the family 2 (PPK2) use polyphosphate to catalyze the reversible phosphorylation of nucleotide phosphates and are highly relevant as targets for new pharmaceutical compounds and as biocatalysts for cofactor regeneration. PPK2s can be classified based on their preference for nucleoside mono- or diphosphates or both. WebFeb 24, 2015 · The metabolism of polyphosphate is important for the virulence of a wide range of pathogenic bacteria and the enzymes of polyphosphate metabolism have been proposed as an anti-bacterial target. In the intracellular pathogen Francisella tularensis, the product of the gene FTT1564 has been identified as a polyphosphate kinase from the …

WebNov 18, 2008 · Inorganic polyphosphate (polyP) is a linear polymer composed of tens to hundreds of orthophosphate residues (P i) linked by the energy-rich phosphoanhydride … WebApr 11, 2024 · Additionally, IPMK serves as a phosphoinositide 3-kinase (PI3k) in mammalian cells 3. The PI3k activity of IPMK, like that of cPI3k enzymes, contributes to AKT activation 3. Independent of its kinase activity, IPMK mediates Jo urn al Pre- pro of autophagy by binding to AMP-dependent protein kinase and the autophagy-activating …

WebNov 18, 2008 · In prokaryotes, the synthesis and utilization of polyP are catalyzed by 2 families of polyP kinases, PPK1 and PPK2, and polyphosphatases. Here, we present …

WebBackground Sucrose non-fermenting-1 (SNF1)-related protein kinase 2 (SnRK2), a plant-specific serine/threonine kinase family, is associated with metabolic responses, including abscisic acid signaling under biotic and abiotic stresses. So far, no information on a genome-wide investigation and stress-mediated expression profiling of jute SnRK2 is … pork loin porterhouse chopsWebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … pork loin pork chop recipesWebSignaling pathways regulated by the phosphoinositide 3-kinase (PI3K) enzymes have a well-established role in cancer development and progression. Over the past 30 years, the therapeutic potential of targeting this pathway has been well recognized, and this has led to the development of a multitude of drugs, some of which have progressed into clinical … pork loin per personWebNov 18, 2015 · The metabolism of polyphosphate is important for the virulence of a wide range of pathogenic bacteria and the enzymes of polyphosphate metabolism have been … pork loin raspberry sauce sharper image giga lite luggage 28 inchWebHematopoietic progenitor kinase 1 (HPK1), also referred to as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), is a serine/threonine kinase that negatively regulates T-cell ... pork loin porchetta roastWebApr 29, 2008 · Primary Citation of Related Structures: 3CZP, 3CZQ. PubMed Abstract: Inorganic polyphosphate (polyP) is a linear polymer of tens or hundreds of phosphate residues linked by high-energy bonds. It is found in all organisms and has been proposed to serve as an energy source in a pre-ATP world. This ubiquitous and abundant biopolymer … sharper image full page floor magnifying lamp