WebThe NADH-dependent enzyme methemoglobin reductase (a type of diaphorase) is responsible for converting methemoglobin back to hemoglobin. Normally one to two … Methemoglobinemia may be acquired. Classical drug causes of methemoglobinaemia include various antibiotics (trimethoprim, sulfonamides, and dapsone ), local anesthetics (especially articaine, benzocaine, prilocaine, and lidocaine ), and aniline dyes, metoclopramide, rasburicase, umbellulone, chlorates, bromates, and nitrites. Nitrates are suspected to cause methemoglobinemia.
Causes of drug induced methemoglobinemia. Download Table
Web19 mrt. 2024 · The most common drugs that cause methemoglobinemia include cocaine-derived anesthetics such as benzocaine and lidocaine, antibiotics such as dapsone, and gases such as nitric oxide. Positive clinical data does exist regarding the benefits of co-administration of cimetidine in patients requiring long-term dapsone therapy. WebThe most clinically relevant direct methaemoglobin formers include local anaesthetics (such as benzocaine and, to a much lesser extent, prilocaine) as well as amyl nitrite and … the complete reference java 2
Methemoglobinemia - UpToDate
WebSome of the medication in benzocaine topical may be absorbed into the bloodstream following local application. When present in sufficient concentrations in the blood, local anesthetics such as benzocaine topical may cause methemoglobinemia, a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen … Web21 jun. 2024 · A French study in 2024 showed that more than 50% of cases of methemoglobinemia with values above 25% in the blood are linked to the use of poppers [].In the adult population as in teenagers, poppers are the second recreational drug taken after cannabis, confirming that it is not restricted to the homosexual community … WebDrugs or toxins that can cause methemoglobinemia 11): Acetanilid Alloxan Aniline Arsine Benzene derivatives Benzocaine Bivalent copper Bismuth subnitrate Bupivacaine hydrochloride Chlorates Chloroquine Chromates Clofazimine Dapsone Dimethyl sulfoxide Dinitrophenol Exhaust fumes Ferricyanide Flutamide Hydroxylamine Lidocaine … the complete reference java book